Fermenter Production fermenter designed with special features for work under aseptic conditions. It is equipped with magnetically coupled agitator, flat turbine impeller that easily can be changed e.g. to marine type propeller. The aeration system allows air flows of up to 2 VVM. Electrode and sample ports are placed in side and in the top cover. Sight glass in top cover. The sparger is easily exchangeable for different methods of aeration. The vessel can be provided with central draft tube. To facilitate cleaning and preparation, the fermenter is mounted tiltable on a stationary stand. Piping and Control Unit The fermenter is provided with a piping and control system enclosed in a stainless steel, floor standing cabinet or mounted in an open frame. In the closed cabinet type the lower part of the cabinet contains valves, circulation pump, heater etc. to conduct gas, steam and water for sparging, sterilisation and temperature control during the process. The gas flow can be set with a manually operated valve and is monitored by a mechanical flow meter. The system may optionally include electronic flow measurement of the gas flow, and regulation through the Novaferm Fermenter Control System by sensor and control valve in the gas inlet line. Sterilisation, cooling and fermentation temperatures are controlled by solenoid and pneumatically operated valves, circulation pump and heater governed from the computer control system. Manometers at the front indicate the pressure of the connected media. The electric cabinet is placed at the upper part of the piping system and contains the electric components, the Novaferm Fermenter Control System and additional instrumentation. The cabinet is provided with fan for forced ventilation. All connections of supply media are placed at the rear of the bottom frame. Control Unit The system is provided with the Novaferm Fermenter Control System for direct digital control of fermentation processes based on programmable logical controllers from the SIMATIC S7 (Siemens) family. The modular concept allows control of fermenter systems from laboratory to industrial scale. The standard control system includes hard- and software for control of temperature, speed and pH and measurement of dissolved oxygen. As an option dissolved oxygen can be cascade controlled by agitator speed and air flow. Additional parameters can be supplied on request. PC hardware is not included in the standard package. Sensor Kit The standard kit contains the following: 2 pcs Pt100 sensors with cables and connectors 1 pce Inductive sensor with cable and connector 1 pce pH sensor (Mettler) with cable and connector 1 pce pO2 sensor (Mettler) with cable and connector 1 pce Foam sensor with cable and connector Additional sensors on request. Dosing Vessel Unit The Unit consists of 3 pcs jacketed pressure vessels, each with a volume of 5 L, mounted on a mobile trolley. The unit is used for addition of e.g. acid, alkali, antifoam agent or other additives. The vessels are easily detachable for filling and cleaning. The unit is connected to compressed air, steam and drain via flexible, pressure safe teflon tubing. The same type of tubing is used for connection of the dosing lines to the fermenter penetrator. Pneumatically actuated diaphragm valves, governed from the Novaferm Fermenter Control System, control the dosing. Pressure can be set with a regulator at the unit. The unit is provided with manometers, safety valves and sterile gas filters. Sterilisation of the system, including the transfer line to the fermenter, can be carried out in situ. As an alternative, a dosing unit with peristaltic pumps can be provided.   Technical Specification Fermenter Vessel, 700 L Vessel Material: Acid resistant stainless steel equal to AISI 316L Working pressure: 3 bar overpressure and full vacuum Conditioning, vessel interior: Ground, grit 220, polished Conditioning, vessel exterior: Ground, grit 180, polished Bottom: Dished, with agitator Jacket Material: Acid resistant stainless steel equal to AISI 316L Working pressure: 3 bar overpressure and full vacuum Lid Material: Acid resistant stainless steel equal to AISI 316L Conditioning: Ground, grit 220, polished Dished, diam. 450 mm, with six clamps Stand Material: Stainless steel Conditioning: Ground, grit 180, brushed Stationary, with platform and tilting possibility. Agitator Bottom mounted, magnetically coupled. Torque 48 Nm, power 4,5 kW, speed 0-1000 rpm Impeller, flat turbine, 6 blades. Other powers on request. Tungsten carbide bearings Seals Material, packings and seals: EPDM Connections Connections in lid: Sight glass, diam. 80 mm Connections in top: 8 pcs E-connections, diam. 25 mm Connections in side, upper level: Gas inlet, gas outlet Connections in side, lower level: 5 pcs E-connections, diam. 25 mm Connections in bottom: 1 pce temp. sensor pocket, diam. 6 mm. 1 pce 1" aseptic bottom drain valve diaphragm type with TC flange outlet Connections in jacket: TC-clamp flanges Sparger Material: Acid resistant stainless steel equal to AISI 316L Nozzle below impeller. Baffles Material: Acid resistant stainless steel equal to AISI 316L With 4 baffle plates. Detachable. Pt 100 pocket Material: Acid resistant stainless steel AISI 316L for Pt 100 sensor Sterile filter Heated filter housing. Capacity 1000 l/min, incl. filter cartridge glass fibre deep filter type, or, with adapter, 0.22 µm hydrophobic PTFE filter cartridge . Accessories Sampler in acid resistant stainless steel equal to AISI 316L. In situ sterilisable Rubber septum connector with 7 holes PTFE-hoses, stainless steel wire reinforced for connection of jacket to steam/condensate and water/drain, aeration and filter jacket to steam and drain Sight glass illumination Seal kit Tool kit Volume Total volume 700 l, working volume 500 l Dimensions H=2300 mm, W=1700 mm, L=1100 mm Vessel diam.=750 mm Weight, approx. 450 kg Design According to the Swedish Code for pressure vessels   Technical Specification Piping and Control Cabinet for Fermenters 700 L MATERIAL Cabinet: Stainless steel Tubing: Stainless steel Components: Stainless steel, brass/gunmetal DESIGN As per Swedish regulations for electrical installations. Electrical parts splash protected, mainly IP54. CONNECTION DATA AUX. AIR Conn. No. 15 Max. consumption 5 l/min free air PROCESS GAS IN Conn. No. 32 Max. consumption 1000 l/min free gas WATER Conn. No. 25 Max. consumption 80 l/min STEAM Conn. No. 25 Rec. min capacity 200 kg/h DRAIN Conn. No. 32 Max. capacity 90 l/min ELECTRICITY Voltage (see below) Max. consumption 10 Kw Gas filter, in Conn. No 25 Gas filter, out Conn. No. 25 Vessel jacket, up Conn. No. 25 Vessel jacket, down Conn. No. 25 Filter jacket, up Conn. No. 8 Filter jacket, down Conn. No. 8 All connections for inlet supplies media are provided with female pipe thread type BSP. MEDIA REQUIREMENTS AUXILIARY AIR Pressure 4-6 bar Dry, particle free PROCESS GAS Pressure 2 bar Dry, oil-free, particle free WATER Pressure 2-4 bar Particle free, max. temp. 5o below min. vessel control temp STEAM Pressure 2 bar Dry, saturated, particle free DRAIN Free flow ELECTRICITY Voltage 3x380V+N+G, 50 Hz Transient free, voltage stability +-5%   Technical Specification Dosing Vessel Unit 3x5 L Vessel Material: Acid resistant stainless steel equal to AISI 316L Design pressure: 8 bar overpressure and full vacuum Conditioning, vessel interior: Ground, grit 220, electropolished Conditioning, vessel exterior: Ground, grit 220, electropolished Bottom: Dished Jacket Material: Acid resistant stainless steel equal to AISI 316L Design pressure: 3 bar overpressure and full vacuum Stand Material: Stainless steel Conditioning: Ground, grit 180, brushed Mobile. Wheels diam. 125 mm, 2 fix, 2 pivoting Seals Material, packings and seals: EPDM Sterile filter Hydrophobic, sterile filter cartridge type Accessories Seal kit Tool kit Volume Total volume 3x5 L Design According to the Swedish Code for pressure vessels

Fermenter System 700 L

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